With the acquisition of Intelligent Biosystems in 2012, Qiagen became a sequencing platform company. So far they haven’t shared too many details on their upcoming platform, the GeneReader, other than it appears to be based on the IBS Mini-20. Originally slated to launch in late 2012, they are now targeting a mid-2014 launch. Like the […]
The latest developments in the next ‘next generation’ sequencing platforms that are promising to dethrone the current market entrants.
General Overview QuantuMDx, while still in ‘semi-stealth mode’, is developing handheld sequencing instruments based on microfluidic channels and nanowires. Q-POC The first instrument they will likely launch is the Q-POC, a handheld clinical short read sequencer. The system will contain a series of nanowires to which template DNA is attached. DNA bases are then […]
Reveo is creating a next-gen sequencer based on atomic force microscopy via their ReVase subsidiary. The system, called the Omni Molecular Recognizer Application (OmniMoRA), will use arrays of nano-knife edge probes to measure the vibrational characteristics of individual bases on DNA molecules that have been stretched and immobilized on a surface. While Reveo has not […]
Stratos Genomics is building a nanopore-based single molecule sequencer. However, rather than directly sequencing the native DNA molecule, they have developed a process they call ‘sequencing-by-expansion’. They convert the DNA into an expanded molecule, or ‘xpandomer’, through a process similar to replication via polymerase. However, rather than incorporating a single base at a time into […]
Two Pore Guys is an early stage technology development company that is attempting to address the issue of DNA flow rate through nanopores. Instead of reading strands of DNA through a single pore, they are using two pores in series such that the DNA molecule is held by both. By applying opposing currents through the […]