Electronic BioSciences is an ‘under the radar’ nanopore sequencing company working on a modified alpha-hemolysin system. Unlike other companies working on highly parallel systems (with thousands of nanopores operating at a time) with relatively low bandwidth per pore, EBS is developing a system with a single pore (possibly growing to a small array of a few pores) with a very fast rate of sequencing of ~50kb/second.
Instead of using disposable cartridges, the EBS system will use a single glass probe on which a lipid bilayer with a single pore will be formed. The small diameter of the glass probe makes the lipid bilayer relatively stable, a problem with larger platforms. The other major difference of the EBS system is that it decouples translocation and readout by using two separate electrical systems, DC for translocation and AC for the readout. This allows for substantially lower noise compared to other systems and also adds the ability to ‘floss’ individual DNA molecules back and forth through the pore, which could help substantially with error rates.
While EBS is expecting long reads (>1kb) in the commercial system, the prototype is currently being used to differentiate stretches of single bases (e.g., A’s vs C’s) and looking at modified/damaged DNA bases.
Projected commercial availability: unknown
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