GenapSys, while still officially in ‘stealth mode’, has started revealing some details of their upcoming platform. Founded in 2010 by Hesaam Esfandyarpour (who was a co-inventor of some of the Stanford patents purchased by Ion Torrent), GenapSys is developing a system based on their label-free GENIUS™ (“Gene Electronic Nano-Integrated Ultra-Sensitive”) technology that they claim will deliver 100-fold improvements on speed and cost.
The system will integrate sample prep, enrichment and sequencing all on a single instrument. The label-free detection will be via both the pH and temperature change that occurs during nucleotide incorporation. While the pH change may sound similar to what Ion Torrent is doing, the company claims their dual sensor system will bring substantial improvements to other sequencers already on the market.
While they haven’t officially revealed any details of their upcoming system, grant abstracts list goals of 1000 base reads and a consumable cost of $50 with an accuracy of 99.7% (listed as ‘pre-assembly accuracy’ which is presumably the same as raw read accuracy).
Projected commercial availability: Q3 2013
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